Our Philosophy
Whether it deals with life sciences, materials, or other areas of high impact, molecular discovery remains a long and tedious process. In practice, developing a new anticancer drug, a new catalyst for asymmetric transformations or a new methodology for "green" synthesis takes years. Our approach is to integrate advanced organic synthesis, computational chemistry, and biological testing to significantly improve the molecular discovery rate.
Areas of Interest
Organic Chemistry, Medicinal Chemistry, and Asymmetric Synthesis
Design, synthesis, and evaluation of potential drugs targeting SARS-CoV-2 key enzymes
Design, synthesis, and evaluation of potential drugs with a focus on Alzheimer's disease and cancer
Development of novel methodologies for the synthesis of chiral cyclic and bicyclic scaffolds
Directing Protecting Groups: a novel concept for green and regioselective transformations of amines and alcohols
Design, synthesis and evaluation of asymmetric catalysts
Computational Chemistry
Development of Fitted - a docking program used for predicting drug binding mode and potency
Development of Impacts - predicting the sites of metabolism of drugs by Cytochrome P450 enzymes
Development of Forecaster - drug discovery at a click of a button
Development of Virtual Chemist - a virtual screening tool in the field of asymmetric catalyst design
Development of H-TEQ - a novel method of obtaining parameters for molecular mechanics calculations
Nucleoside modeling for streamlining the synthesis of nucleoside-based drugs
Integrated Experimental and Computational Chemistry
Computer-aided design and synthesis of novel asymmetric catalysts
Computer-aided design and synthesis of novel asymmetric catalysts
Towards the development of novel compounds integrating medicinal and computational chemistry
An In-depth look at our research projects
Developing drugs targeting SARS-CoV-2 to treat COVID-19 - See project details here
Targeting serine protases to treat cancer and neurodegenerative diseases - See project details here
Targetting dipeptidyl peptidase 8/9 (DPP8/9) for cancer immunotherapy - See project details here
Targeting activation-induced cytidinde deaminase (AID) for the treatment of leukemia - See project details here
Fighting against metabolic drug resistance - See project details here
Predicting sites of metabolism, reactive metabolite formation and CYP inhibition - See project details here
Improving molecular mechanics using chemistry principlesand the H-TEQ method - See project details here
Designing asymmetric catalysis with the Virtual Chemist platform - See project details here
Funding Agencies and Partners
